HORDB

ID: hor001933
Uniprot ID: Q9PUR0
Protein name: Glucagon-like peptide 2
Gene name: gcg2
Organism: Petromyzon marinus (Sea lamprey)
Family: Glucagon family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Petromyzon (genus), Petromyzontidae (family), Petromyzontiformes (order), Hyperoartia (class), Cyclostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Sequence: HSDGSFTNDMNVMLDRMSAKNFLEWLKQQGRG
Length: 32(89-120)
Propeptide: MSNASGTLLSYMFMMLLGLTLASLVPHETDDGDLNAEISLANRHSQGSFTSDYSKHLDVKQAKDFVTWLLNTKRRGVDAQAGANLEKRHSDGSFTNDMNVMLDRMSAKNFLEWLKQQGRG
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001933_AF2.pdb

hor001933_ESM.pdb

Mass:	426729	Formula:	C158H246N48O50S3
Absent amino acids:	CIPY	Common amino acids:	DGLMNS
pI:	7.55	Basic residues:	5
Polar residues:	10	Hydrophobic residues:	8
Hydrophobicity:	-87.5	Boman Index:	-8357
Half-Life / Aliphatic Index:	3.5 hour	Aliphatic Index:	48.75
Instability Index:	1894.06	Extinction Coefficient cystines:	5500
Absorbance 280nm:	177.42